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It’s natural for parents, families, and people with ADHD to become overwhelmed when faced with the task of managing the genetic mutations MTHFR and COMT. After all, navigating through the world of genetics can feel like a daunting prospect, especially for those who have little prior knowledge in this field. But don’t worry! We’re here to help shed some light on the subject by introducing Functional Medicine—an approach that not only helps you better understand your body but also brings us one step closer to targeting these mutations. With functional medicine offering invaluable guidance, together we can bridge the gap between understanding MTHFR and COMT and improving associated ADHD symptoms.


Introducing MTHFR and COMT – What They Are and How They Affect ADHD

Let’s geek out for a moment and talk about MTHFR and COMT. These genetic mutations may sound like a mouthful, but they play an important role in our overall health, particularly when it comes to ADHD.  So, what exactly are they and how do they impact us? First up is MTHFR (Methylenetetrahydrofolate Reductase). This gene is responsible for creating an enzyme that helps break down and process homocysteine, an amino acid that’s been linked to a whole host of health issues. However, when MTHFR isn’t functioning properly due to a mutation, homocysteine levels can soar, leading to a slew of problems, including ADHD. This gene mutation could lead to methylation imbalances that affect neurotransmitter production like Dopamine and Epinephrine and Norepinephrine, ultimately impacting mood, behavior, and attention. Now, let’s move on to COMT. COMT is another gene that produces an enzyme, catechol-O-methyltransferase, which helps break down certain neurotransmitters like dopamine, epinephrine, and norepinephrine.  COMT mutations can result in either increased or decreased enzyme activity, which can impact the breakdown and processing of these neurotransmitters. Specifically, individuals with the COMT Val/Val genotype have been shown to have lower levels of dopamine in certain areas of the brain, which can contribute to symptoms of ADHD.  Additionally, research has shown that COMT mutations may also impact the body’s response to stress. This is because the COMT enzyme plays a key role in breaking down and eliminating stress hormones like cortisol and adrenaline ( epinephrine).


When the COMT enzyme isn’t functioning properly, the body may be less effective at managing stress, which can lead to a range of physical and mental health problems, including anxiety, depression, and ADHD. Testing for MTHFR and COMT Have you ever wondered about your genetic makeup and how it might impact your health? Well, there are ways you can test for specific genetic mutations like MTHFR and COMT. You can go the DNA testing kit route, which involves spitting into a tube and sending it off for analysis. This can be done through popular services such as 23andMe or AncestryDNA, which provide reports on various genetic traits and health conditions. Or, you could work with a functional medicine practitioner to get more detailed testing. Once you find out your specific mutations, there are nutraceutical treatments available to help support your body’s needs. By taking a functional medicine approach that addresses underlying imbalances and supports healthy methylation and neurotransmitter production, individuals with these mutations can take steps to manage their symptoms and improve their overall quality of life. 


Nutraceuticals and Lifestyle Shifts 

Fortunately, there are many natural treatments that can help manage these mutations and improve the symptoms of ADHD. One such treatment is called nutraceuticals, which involves supplementing with specific nutrients and compounds that support healthy brain function and neurotransmitter production. For example, individuals with MTHFR mutations may benefit from supplementing with methylfolate, which is a form of folate that is easily absorbed and utilized by the body. This can help support healthy methylation and improve neurotransmitter production. 


Similarly, individuals with COMT mutations may benefit from supplementing with certain amino acids like tyrosine, which is a precursor to dopamine production. By providing the body with the building blocks it needs to produce neurotransmitters, these supplements can help improve the symptoms of ADHD and other related conditions.


In addition to nutrient supplementation, dietary changes can also be beneficial. For example, a diet rich in leafy greens, beets, and other foods high in folate can help support healthy methylation, while a diet rich in protein and healthy fats can provide the building blocks needed for neurotransmitter production.

Other lifestyle changes can also be helpful, such as stress management techniques like meditation or yoga, regular exercise, and getting adequate sleep. By reducing stress and supporting overall health, individuals with MTHFR and COMT mutations can improve their overall well-being and reduce symptoms of ADHD.


The Caring Touch of Functional Medicine 

Working with a functional medicine practitioner can be particularly helpful for managing these genetic mutations and improving ADHD symptoms. We can order specific genetic testing panels to identify mutations like MTHFR and COMT and provide personalized treatment plans based on the individual’s unique needs and challenges. Everybody experiences imbalances in their bodies—some people more than others. For those with certain mutations that cause disruptions to methylation and neurotransmitter production, it can be challenging to manage symptoms and maintain a good quality of life. But with the right strategies, personalized plans, and interventions through a functional medicine approach, such as key nutrient supplementation and lifestyle modifications, it’s possible not just to manage symptoms but also to address any underlying imbalances, significantly improving overall well-being.


It is clear that when the right steps are taken, having a child with ADHD who may have MTHFR and COMT mutations can be managed in a way that works best for their overall needs. Recognizing early on the impact of these mutations is key to providing the support they need, as well as understanding how functional medicine can help address them. Through targeted nutraceuticals and lifestyle changes, parents can improve their child’s condition with ease. Moreover, when provided with a caring touch, functional medicine can truly bridge the gap between the emotional and physical aspects of ADHD for those living with MTHFR and COMT mutations. If you’re looking to make real gains in your child’s development and well-being, framed by compassionate care, reach out to Covington Pediatrics now at 770-787-7444 to schedule a consultation today.


Looking for a way to take care of your family’s health in a more natural way? Don’t miss out on our Private Facebook Group – it’s like having a virtual wellness tribe at your fingertips! And if you want to take things to the next level, book an appointment with us at 770-787-7444. Let’s see if our approach is the perfect fit for your loved ones’ unique needs.





DISCLAIMER:  The information in this email is not intended nor implied to be a substitute for professional medical advice, diagnosis, or treatment. All content is for general informational purposes only and does not replace a consultation with your own doctor/health professional.